An open trial of levetiracetam for segmental and generalized dystonia
Identifieur interne : 003024 ( Main/Exploration ); précédent : 003023; suivant : 003025An open trial of levetiracetam for segmental and generalized dystonia
Auteurs : Sascha Hering [Autriche] ; Gregor K. Wenning [Autriche] ; Klaus Seppi [Autriche] ; Werner Poewe [Autriche] ; Joerg Mueller [Autriche]Source :
- Movement Disorders [ 0885-3185 ] ; 2007-08-15.
Descripteurs français
- Pascal (Inist)
English descriptors
- KwdEn :
- Adult, Aged, Anticonvulsants (therapeutic use), Bontoxilysin, Dystonia, Dystonia (classification), Dystonia (drug therapy), Female, Follow-Up Studies, Humans, Levetiracetam, Male, Middle Aged, Nervous system diseases, Piracetam (analogs & derivatives), Piracetam (therapeutic use), Treatment Outcome, botulinum toxin, dystonia, levetiracetam.
- MESH :
- chemical , analogs & derivatives : Piracetam.
- chemical , therapeutic use : Anticonvulsants, Piracetam.
- classification : Dystonia.
- drug therapy : Dystonia.
- Adult, Aged, Female, Follow-Up Studies, Humans, Male, Middle Aged, Treatment Outcome.
Abstract
Local botulinum toxin injections represent the treatment of choice for most patients with focal dystonia. However, patients with segmental or generalized forms require additional pharmacologic treatment which is often ineffective or limited by intolerable side‐effects. An animal study and three case reports suggested antidystonic effects of levetiracetam, a pyrrolidone derivate, whereas a recent open‐label study found no improvement in 10 patients with primary idiopathic cervical dystonia. We studied the efficacy of levetiracetam in a daily dose of 3000 mg in 10 consecutive patients with otherwise therapy refractory segmental or generalized dystonia. At 4‐week follow‐up, none of the patients showed improvement of dystonia, mild side‐effects were observed in 3 patients. © 2007 Movement Disorder Society
Url:
DOI: 10.1002/mds.21597
Affiliations:
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Le document en format XML
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Disord.</title><idno type="ISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="2007-08-15">2007-08-15</date><biblScope unit="vol">22</biblScope><biblScope unit="issue">11</biblScope><biblScope unit="page" from="1649">1649</biblScope><biblScope unit="page" to="1651">1651</biblScope></imprint><idno type="ISSN">0885-3185</idno></series><idno type="istex">4FBF93BD2E14338803CFB46E2D90BBE3A191379E</idno><idno type="DOI">10.1002/mds.21597</idno><idno type="ArticleID">MDS21597</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term><term>Aged</term><term>Anticonvulsants (therapeutic use)</term><term>Bontoxilysin</term><term>Dystonia</term><term>Dystonia (classification)</term><term>Dystonia (drug therapy)</term><term>Female</term><term>Follow-Up Studies</term><term>Humans</term><term>Levetiracetam</term><term>Male</term><term>Middle Aged</term><term>Nervous system diseases</term><term>Piracetam (analogs & derivatives)</term><term>Piracetam (therapeutic use)</term><term>Treatment Outcome</term><term>botulinum toxin</term><term>dystonia</term><term>levetiracetam</term></keywords><keywords scheme="MESH" type="chemical" qualifier="analogs & derivatives" xml:lang="en"><term>Piracetam</term></keywords><keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Anticonvulsants</term><term>Piracetam</term></keywords><keywords scheme="MESH" qualifier="classification" xml:lang="en"><term>Dystonia</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Dystonia</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Aged</term><term>Female</term><term>Follow-Up Studies</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Treatment Outcome</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Bontoxilysin</term><term>Dystonie</term><term>Lévétiracétam</term><term>Système nerveux pathologie</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Local botulinum toxin injections represent the treatment of choice for most patients with focal dystonia. However, patients with segmental or generalized forms require additional pharmacologic treatment which is often ineffective or limited by intolerable side‐effects. An animal study and three case reports suggested antidystonic effects of levetiracetam, a pyrrolidone derivate, whereas a recent open‐label study found no improvement in 10 patients with primary idiopathic cervical dystonia. We studied the efficacy of levetiracetam in a daily dose of 3000 mg in 10 consecutive patients with otherwise therapy refractory segmental or generalized dystonia. At 4‐week follow‐up, none of the patients showed improvement of dystonia, mild side‐effects were observed in 3 patients. © 2007 Movement Disorder Society</div></front></TEI><affiliations><list><country><li>Autriche</li></country><region><li>Tyrol (Land)</li></region><settlement><li>Innsbruck</li></settlement><orgName><li>Université de médecine d'Innsbruck</li></orgName></list><tree><country name="Autriche"><noRegion><name sortKey="Hering, Sascha" sort="Hering, Sascha" uniqKey="Hering S" first="Sascha" last="Hering">Sascha Hering</name></noRegion><name sortKey="Mueller, Joerg" sort="Mueller, Joerg" uniqKey="Mueller J" first="Joerg" last="Mueller">Joerg Mueller</name><name sortKey="Poewe, Werner" sort="Poewe, Werner" uniqKey="Poewe W" first="Werner" last="Poewe">Werner Poewe</name><name sortKey="Seppi, Klaus" sort="Seppi, Klaus" uniqKey="Seppi K" first="Klaus" last="Seppi">Klaus Seppi</name><name sortKey="Wenning, Gregor K" sort="Wenning, Gregor K" uniqKey="Wenning G" first="Gregor K." last="Wenning">Gregor K. Wenning</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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